Critical analysis of prostate-specific antigen doubling time calculation methodology
نویسندگان
چکیده
منابع مشابه
Investigation of the relationship between prostate specific antigen doubling time and the severity of a malignant tumor of the prostate
Background: Prostate cancer has been reported as a worldwide important kind of cancer and the second most common cause of cancer-related mortality among men. Prostate-specific antigen (PSA) serum level is one of the most important markers of prostate cancer diagnosis. While PSA level helps predict the risk of prostate cancer development, researchers still looking for ways to increase the accura...
متن کاملUsing prostate-specific antigen doubling time in clinical practice.
Isolated PSA failures after definitive local therapy might precede clinically evident manifestations of recurrent disease by many years [1,2]. These biochemical failures might represent local recurrences, distant recurrences, or both, and accurately determining the site of recurrence early remains a diagnostic challenge. Independent of pretreatment and prostatectomy disease features (i.e. pretr...
متن کاملAge Specific Reference Levels of Serum Prostate-Specific Antigen, Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men
Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific antigen (PSA) concentration and PSA density (PSAD) and prostate volumes in a population of he...
متن کاملProstate-specific antigen doubling time as a predictor of Gleason grade in prostate cancer.
INTRODUCTION Our aim was to evaluate the value of serum prostate-specific antigen doubling time (PSADT) to identify patients with high-grade prostate cancer who require more aggressive therapy from those with low-grade cancer. MATERIALS AND METHODS Of 460 patients with extended 12-core transrectal ultrasonography-guided biopsy of the prostate, 59 with confirmed prostate cancer were selected. ...
متن کاملAssociation between prostate specific antigen change over time and prostate cancer recurrence risk: a joint model
Background: Prostate specific antigen (PSA) is an important biomarker to monitor patients after treated with radiation therapy (RT). The aim of this study is to evaluate the relationship between the PSA data and prostate cancer recurrence using the joint modeling. Methods: This historical cohort study was performed on 422 prostate cancer patients. Inclusion criteria included: patients with loc...
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ژورنال
عنوان ژورنال: Cancer
سال: 2006
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.21696